The TMPO-AS1/hsa-let-7b-5p regulatory axis shapes transcriptional heterogeneity and immune landscape in lung adenocarcinoma.

Cell Div · 2026 · PMC13200321 · PMID 41975423

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highly significantno p-value reported

Among the positively associated genes (TGFBR3, RNF144B, and CD59), a combined analysis showed a highly significant negative correlation with nTreg immune cells ( R = −0.53, −0.56, and − 0.37, respectively), indicating that increased expression of such genes may inhibit the anti-cancer immune response of nTreg.

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