Psilocybin ameliorates neuropathic pain-like behaviour in mice and facilitates gabapentin-mediated analgesia.

An overall trend toward an increase in the time spent on the cold plate was observed ( P = 0.085), compared to saline-injected mice which reached significance by day 30 (Bonferroni corrections P = 0.02) (Fig. 1E ) (psilocybin, 65.1 ± 23.4 s; saline, 18.9 s ± 3.6 s) Psilocybin (1 mg/kg) also had no adverse effect on locomotor performance in naïve male mice (Supplementary Fig 2A-B ).

also in 4,871 other papers