A QbD optimization of a pH-responsive Eudragit S100-chitosan nanoformulation for the co-delivery of pentoxifylline and simvastatin in colorectal cancer therapy.

Analysis of variance for particle size ( Table 4 ) demonstrated that the quadratic model was highly significant ( F = 42.18, p < 0.001) with an excellent coefficient of determination ( R 2 = 0.9870), indicating that 98.7% of the variability in particle size can be explained by the model.

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