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The impact of opioid prescribing guidelines on opioid dispensation: A systematic review and meta-analysis.

Can J Pain · 2026 · PMC13203043 · PMID 42205979

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an increasing trendno p-value reported
Chronic noncancer pain The effect of the guidelines on prevalence remains unclear, with nine studies reporting an increasing trend 52 , 53 , 85–91 and nine studies reporting a decreasing trend. 23 , 49 , 91–97 Four studies reported no changes or post-guideline prevalence that varied depending on the specific guideline examined (e.g., APS-AAPM versus CDC). 50 , 54 , 96 , 98 However, the guidelines’ effects on the incidence were

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a decreasing trendno p-value reported
Chronic noncancer pain The effect of the guidelines on prevalence remains unclear, with nine studies reporting an increasing trend 52 , 53 , 85–91 and nine studies reporting a decreasing trend. 23 , 49 , 91–97 Four studies reported no changes or post-guideline prevalence that varied depending on the specific guideline examined (e.g., APS-AAPM versus CDC). 50 , 54 , 96 , 98 However, the guidelines’ effects on the incidence were clearer, with seven studies showing a decrease, 87 , 90 , 99–

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.