Hepatocarcinogenesis in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Emerging Roles of Interleukin-10 and Transcriptomic Insights into IL-10 Signaling Rewiring.

Consistent with the limma-voom F-test above, a one-way ANOVA on log2-CPM values (unweighted) confirmed the same genes as the stage-variable: Il10ra (F = 16.6, p = 2.7 × 10 −8 ), Il10rb (F = 28.8, p = 2.6 × 10 −11 ), and Scd2 (F = 12.0, p = 1.0 × 10 −6 ) showed highly significant stage-dependent variation, with pairwise Holm-adjusted Mann–Whitney comparisons confirming that Control, Early MASLD, and MASH differed significantly from HCC for each of these genes.

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