Preliminary Analysis of the Proportion and Characteristics of Dual BCR B Cells in SLE Model Mice and Patients via scRNA-Seq Combined with scBCR-Seq Technology.

Cells · 2026 · PMC13204964 · PMID 42193924

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an increasing trendno p-value reported

In this study, we observed an increasing trend of Breg cells in both SLE model mice and SLE patients, consistent with previous reports [ 48 ].

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a decreasing trendno p-value reported

The results showed: (1) Compared with control groups, the proportion of dual BCR B cells in SLE model mice and patients exhibited a decreasing trend, whereas the diversity of the CDR3 repertoire decreased and clonality increased.

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