Novel Monoclonal Antibody Detects Small Aβ Oligomers More Sensitively Than Lecanemab in Alzheimer's Disease CSF, Serum and Culture Media.

In these samples, we previously reported a highly significant positive correlation between the 71A1/3D6 oligomer values and both total tau ( r = 0.71, * p < 0.0001; Fig 3A ) and phospho‐tau 181 ( r = 0.70, * p < 0.0001; Pearson correlation coefficients; Fig 3B ) and no significant correlation with Aβ1‐42 monomer levels (Fig 3C ). 21 A separate cohort of control CSFs from 40 young (mid‐30s), healthy control individuals was also assayed, and their CSF 71A1 oAβ levels were compared with the patients from the BWH MAC cohort after further stratification.

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