Development of a Lysine-Reactive Targeted Covalent Inhibitor for the P300/CBP-Associated Factor Bromodomain Through Structure-Based Design.

ChemMedChem · 2026 · PMC13206289 · PMID 42174376

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highly significantno p-value reported

Data obtained shows that treatment of PCAF bromodomain with 10 resulted in a highly significant +20°C stabilization (Figure 6C ).

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