Plant-Derived Compounds as Potential Sensitizers to Immunotherapy in Melanoma.

Chemical derivatization strategies Chemical derivatization has emerged as another strategy to optimize luteolin’s pharmacokinetic profile by modulating its physicochemical properties; this strategy is particularly relevant for luteolin that displays numerous phenolic hydroxyl groups that, although highly significant for its redox biological activity, strongly contributes to its low membrane permeability, high instability within physiological environments, and fast phase II metabolism (glucuronidation, sulfation).

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