Integrated Transcriptomic and Spatial Analyses Associate M2-like Myeloid Signatures with Neuroimmune Remodeling in Alzheimer's Disease.

Analysis of specific myeloid cell populations revealed an increasing trend in the Z-scores for total macrophages, M1 macrophages, and M2 macrophages from healthy to AD groups, suggesting heightened macrophage infiltration and potential neuroinflammatory activity as AD progresses ( Figure 3 D).

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Concurrently, neuronal levels, represented by xCell Z-scores, showed a decreasing trend across the AD continuum (healthy, pre-AD, AD groups).

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MCPcounter (Macrophage/Monocyte, p = 1.140 × 10 −17 , ****) and TIMER (Macrophages, p = 1.314 × 10 −20 , ****) also demonstrated highly significant increases in macrophage populations in AD.

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