highly significantp < 0.001
The progressive nature of the IOP reduction was confirmed by a linear mixed-effects model with a random intercept for patient (n = 232 observations from 29 patient clusters): all time main effects were highly significant (Day 30 vs. baseline β = −6.12, 95% CI −6.93 to −5.30, p < 0.001; Day 90 β = −7.56, 95% CI −8.37 to −6.74, p < 0.001; Day 180 β = −8.56, 95% CI −9.37 to −7.74, p < 0.001).