highly significantp < 0.001
In the normal-flow subgroup, between-arm differences were pronounced and highly significant across all three outcomes: VSC (Δ −20.2 ± 33.2 standard vs. −55.1 ± 42.7 probiotic vs. −85.7 ± 34.0 zinc; p < 0.001), organoleptic (Δ −0.2 ± 0.7 vs. −0.9 ± 0.8 vs. −1.3 ± 0.8; p < 0.001), and HALT (Δ −11.4 ± 7.0 vs. −17.5 ± 7.0 vs. −22.8 ± 7.0; p < 0.001).