Protective Role of Alpha-Lipoic Acid Against Methotrexate-Induced Osteotoxicity: Mechanisms of Oxidative Stress Regulation and MAPK Pathway Inhibition.

Pharmaceuticals (Basel) · 2026 · PMC13209593 · PMID 42198403

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highly significantno p-value reported

Across all evaluated parameters—including apoptotic mediators, MAPK signaling components, and oxidative stress markers—the co-treatment with ALA (MTX+ALA group) yielded a highly significant improvement compared to the MTX-only group.

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