Crystal Engineering as an Efficient Medicinal Chemistry Tool for Animal PK Bioavailability Enhancement in Early Pre-Clinical Research.

It can be seen that the 2,4-DHBA co-crystal form 24-1 exhibits lower heat capacities in the investigated temperature range of 25–65 °C (0.97–1.07 J/g×K) compared to the 3,4-DHBA co-crystal form 34-1 (1.17–1.24 J/g×K); however, these differences are at best borderline significant based on the observed scattering of data derived from standard deviations (0.11–0.14 J/g×K) within multiple determinations per form.

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