KPC-2 Orchestrates Systemic Metabolic Rewiring to Facilitate Antibiotic Adaptation in <i>Klebsiella pneumoniae</i>.

Microorganisms · 2026 · PMC13210117 · PMID 42197440

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Orthogonal partial least squares-discriminant analysis (OPLS-DA) revealed a profound and highly significant metabolic divergence between the KPC-2-carrying group and the control group, indicating that the acquisition of this resistance gene fundamentally alters the host’s biochemical state.

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KPC-2 Orchestrates Systemic Metabolic Rewiring to Facilitate Antibiotic Adaptation in &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt;.

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KPC-2 Orchestrates Systemic Metabolic Rewiring to Facilitate Antibiotic Adaptation in <i>Klebsiella pneumoniae</i>.