Lipid Nanoparticle-Encapsulated PolyI:C as an Adjuvant Enhances Both Humoral and Cellular Immune Responses to the Hepatitis B Vaccine.

Vaccines (Basel) · 2026 · PMC13211435 · PMID 42188770

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an increasing trendno p-value reported

The data from this study support this mechanism: following the addition of PolyI:C, IgG2a levels on both D14 and D28 showed an increasing trend, confirming the directional driving effect of PolyI:C on Th1 polarization.

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