MicroRNA-200s attenuate demyelination caused by Angiostrongylus cantonensis in a mouse model by targeting phosphatase and tensin homolog.

Combined overexpression of miR-200a and miR-200c reduces demyelination in Angiostrongylus cantonensis -infected mice Given the aforementioned results showing that miR-200a and miR-200c may be significant in AC infection, we next asked whether they exert their effects separately or synergistically. miR-200a and miR-200c were administered to AC-infected mice at 7 dpi to maintain high expression levels of both miRNAs in the mouse brain ( Figure 2A ).

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