Nuclear accumulation of PANK4 in hippocampal astrocytes aggravates cuproptosis in association with mild cognitive impairment in aged mice.

Hippocampal WB analysis ( Figure 3A ) revealed significant age-dependent upregulation of cuproptosis regulators in 18M+WT mice versus young controls: FDX1 increased [One-way ANOVA: F (2, 13) = 8.739, p = 0.0039; Figures 3B,C ]; LIAS increased [One-way ANOVA: F (2, 13) = 10.95, p = 0.0016; Figures 3B,D ]; DLAT showed a decreasing trend [One-way ANOVA: F (2, 13) = 6.248, p = 0.01225; Figures 3B,E ].

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Cytoplasmic PANK4 levels showed an increasing trend in aged WT mice [One-way ANOVA: F (2, 13) = 4.242, p = 0.0382; Figures 2D,G ], with significant reduction in Pank4-CKO versus 18M+WT ( p = 0.0488).

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