Three genes, ZNF48 (Spearman’s R: 0.30; p = 9.7e-5 in PTSD + CI; Spearman’s R: 0.33; p = 1.8e-5 in PTSDΔCI), TOMM40 (Spearman’s R: –0.31; p = 1.1e-4 in PTSD + CI; Spearman’s R: –0.34; p = 2.7e-5 in PTSDΔCI), and GRIN1 (Spearman’s R: 0.29; p = 1.9e-5 in PTSD + CI; Spearman’s R: 0.33; p = 9.6e-7 in PTSDΔCI), shown consistent, highly significant correlations that survived Bonferroni correction in both PTSD + CI and PTSDΔCI.
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Mechanistic signatures of comorbid PTSD with cognitive impairment implicate cortisol-induced neural toxicity.
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