Latrepirdine (Dimebon), a potent 5-HT<sub>7</sub> receptor antagonist, modulates stress-mediated behaviors in rodents.

During the 20 mg/kg treatment phase, days 8–11, there was a highly significant difference between vehicle and the 20 mg/kg dosed groups [Immobility time: F (1, 44) = 7.101; p = 0.0107] On days 12–15 the dose of latrepirdine was increased to 40 mg/kg to determine if the 20 mg/kg dose was achieving the maximal effect.

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