highly significantp<0.0001
This difference was highly significant (p<0.0001).
This difference was highly significant (p<0.0001).
Similarly, DBP from the same four studies did not differ significantly, although there was a nonsignificant trend towards lower DBP in the COPD group (MD −2.25 mmHg, 95% CI −6.13 to +1.64 mmHg; I 2 =0%) ( figure 3b ).