Once-Weekly Semaglutide in Adults With Daily Cigarette Use: A Randomized Clinical Trial.

The preplanned LMMs for delay time and laboratory cigarettes smoked yielded no significant treatment-by-time interactions (delay time: β = 0.16 [95% CI, −0.07 to 0.40]; P = .16; cigarettes smoked: β = −0.08 [95% CI, −0.25 to 0.08]; P = .30), and the medication condition effect failed to reach significance for delay time β = −0.24 [95% CI −0.67 to 0.18]; P = .25) and cigarettes consumed (β = 0.34 [95% CI −0.04 to 0.73]; P = .08) (eTable 2 in Supplement 2 ).

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