Limited Nrf2 activation and heterogeneous thyroidal effects in a 424-compound multi-assay screen call for rigorous testing of purported antioxidant and health-promoting supplements.

Chi-square analysis revealed a highly significant 8-fold enrichment of chalcones compared to the total library (17.2% vs. 2.1%, χ 2 = 34.6, df = 1, p < 0.0001), whereas phenolic compounds (χ 2 = 3.5, df = 1, p = 0.0627) and alkaloids (χ 2 = 0.009, df = 1, p = 0.9257) did not show significant enrichment (Fig. 2C and. 5 D). 3.3.

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