State-specific inhibition of NMDA receptors by memantine provides insight into NMDAR channel blocker tolerability.

Larger increases in [Ca 2+ ] i consistent with pathological conditions resulted in larger and highly significant increases in memantine potency (IC 50 = 1.76 ± 0.12 μM at [Ca 2+ ] i = 100 nM versus IC 50 ~ 0.7 μM at [Ca 2+ ] i = 5–50 μM; P < 0.01).

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