Reprogramming Transcriptional Networks via CREB1 Lactylation at K122 Activates HMGB1-Mediated NETosis and Chemoresistance.

Int J Biol Sci · 2026 · PMC13215458 · PMID 42212318

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highly significantP =1.0 × 10 -125actually significant

Compared to size-matched random genomic regions, K122Q-bound enhancers showed highly significant enrichment of the canonical CRE motif (Fold Enrichment=13.7, P =1.0 × 10 -125 ), with 42.5% of enhancers containing the motif versus 3.1% of background regions ( Supplementary Fig. 2 ).

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