MTSS1-dependent ubiquitin modifications mediated by FBXO44 remodel the actin cytoskeleton to promote gastric cancer progression.

Mol Cancer · 2026 · PMC13217682 · PMID 41998764

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an increasing trendno p-value reported

Elevated quantitative IHC scoring revealed an increasing trend in FBXO44 positivity from normal adjacent tissues (AT) (FBXO44 positive rate: 7.5%) to primary tumor tissues (PR) (FBXO44 positive rate: 22%) and metastatic lymph nodes (MLN) (FBXO44 positive rate: 18.6%), with the highest expression observed in distant metastases (M1 stage positive rate was 37.8%) (Fig. 1 B).

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