Functional sQTLs regulating PTK2B exon 31 splicing uncover an RNA-dependent modulation of its kinase activity and cellular phenotype.

Cell Commun Signal · 2026 · PMC13217868 · PMID 41928225

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a decreasing trendno p-value reported

In THP-1 cells, which harbor the rs751019-A allele as confirmed by Sanger sequencing, knockdown of PCBP1 or PCBP2 alone did not significantly alter exon 31 inclusion, although a decreasing trend was observed.

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