Recapitulation of clinical and molecular hallmarks of lipid-induced hepatic insulin resistance in a zonated, vascularized human liver acinus microphysiological system during metabolic dysfunction-associated steatotic liver disease (MASLD) progression.

BMC Biotechnol · 2026 · PMC13217926 · PMID 42063103

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[ 19 , 94 , 95 ] An elevated nuclear FOXO1 signal in comparison to its cytoplasmic signal across the sum in all zones was observed under LMS conditions, with an increasing trend under EMS compared to NF conditions (Fig. 4 B).

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