Neurogranin negatively regulates gene expression and proinflammatory mediator release in allergen-activated mast cells.

Immunohorizons · 2026 · PMC13218791 · PMID 42209411

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an increasing trendno p-value reported

39 At the messenger RNA level, Ng deficiency was observed to increase IL-6 and IL-13 gene expression and additionally resulted in an increasing trend in TNF, CCL1, and CCL3, with no effect on CCL2.

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did not quite reach statistical significanceno p-value reported

Coinciding with the observed reduction of Nrgn in Nrgn +/− cells, Nrgn protein levels were ∼25% reduced in Nrgn +/− cells compared with Nrgn +/+ , though this did not quite reach statistical significance ( Fig. 1D ).

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