Barely Significant
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Influence of the broadly neutralizing antibody VRC01 on HIV breakthrough virus populations in antibody-mediated prevention trials.

Nat Commun · 2026 · PMC13219488 · PMID 41932899

Europe PMCDOI
1
hedged sentence
0.0700
closest p · 1.4× alpha
0.0700
boldest claim

The sentences

a trend toward significancep = 0.07so close (0.05 < p ≤ 0.1)
The frequency of minor GP lineages in the placebo group was lower in the VRC01 group (14%; 15/105) compared to those in REN (25%; 17/67), with a trend toward significance (Fisher’s exact test two sided: p = 0.07) Recombination was pervasive, as revealed in individuals with multilineage infections.

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