a nonsignificant trendp = 0.12
Grade I tumors exhibited a nonsignificant trend toward reduced survival in the high-expression group (HR = 2.01, 95% CI: 0.82–4.89, p = 0.12) ( Fig. 4 A), while significant survival differences were observed in grade II (HR = 1.63, 95% CI: 1.09–2.44, p = 0.017) and grade III tumors (HR = 1.97, 95% CI: 1.15–3.37, p = 0.012) ( Fig. 4 B,C).