MIAAIM: Multi-omics image integration with dimensional reduction for tissue state mapping.

Interestingly, we found that correlations to Ki-67 expression shifted with near significance ( 2 σ ) for multiple m/z peaks (Fisher transformed, one-sided z-statistics; Bonferroni corrected P-values) between CD3 − populations and the CD3 + population ( Fig 3h ), suggesting molecular candidates associated with proliferation in these cells.

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The proto-oncogene c-Myc and CXCR3 are known biomarkers of prostate cancer tumorigenesis and progression [ 54 – 57 ], and were top IMC predictors, showing an increasing trend in expression as a function of Gleason score up to the 4 + 5 class ( Fig 4e ).

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