Association of CTI and its obesity-related derivatives with incident depression among middle-aged and older adults across CKM stages 0-4: a nationwide prospective cohort study and external clinical validation.

Front Endocrinol (Lausanne) · 2026 · PMC13229798 · PMID 42244946

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highly significantno p-value reported

The inverse association of elevated CTI-CVAI against depression was highly significant among participants aged < 60 years (baseline HR: 0.88, 95% CI: 0.82-0.95; cumulative HR: 0.89, 95% CI: 0.82-0.96).

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