Lifestyle shapes genome architecture and codon usage bias in <i>Staphylococcus aureus</i> bacteriophages, suggesting stronger host adaptation in their virulent lineages.

The nonparametric Kruskal–Wallis tests indicated highly significant global differences for all the examined metrics except the nt patterns ( Table 4 ): the strongest lifestyle effect was observed at %GC3, which exhibited a large effect size (ε 2 = 0.324; H = 2658.519; p < 0.001), indicating that approximately one-third of the variance in GC3 among genes can be attributed to lifestyle differences.

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