Identifying clinically relevant cell state interactions in the tumor microenvironment of IDH-mutant gliomas using CSI-TME.

We calculated the penetrance of pro- and anti-tumor CSIs in these patients (“Methods”) and, encouragingly, we observed that the penetrance of pro-tumor interactions was significantly higher in non-responders than in responders, and the converse was true for anti-tumor CSI, although the latter achieved only marginal significance, possibly due to only four anti-tumor CSIs being used (Fig. 6A ).

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