WFS1 gene delivery rescues visual function in a mouse model of Wolfram syndrome.

Acta Neuropathol Commun · 2026 · PMC13231592 · PMID 41998758

Europe PMC DOI

hedged sentences

0.0360

closest p · 0.7× alpha

0.0360

boldest claim

The sentences

almost significantp = 0.036actually significant

At 6 months, however, the WT had a similar level of 129.9 ± 4.7 mg/dL to that at 3 months, whereas the KOs had an increase of 191.4 ± 29.7 mg/dL, which was almost significant ( p = 0.036).

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an apparent trendno p-value reported

We did not observe a significant increase in ER stress in the retina of 6.5-month-old KO mice, although there was an apparent trend toward increased BiP expression in the retinas of mutant mice.

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