Transcriptome-constrained genome-scale metabolic modeling reveals central carbon and amino acid metabolic reprogramming underlying colistin-sulbactam synergy in <i>Acinetobacter baumannii</i>.

Antimicrob Agents Chemother · 2026 · PMC13231871 · PMID 42084367

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an overall trendno p-value reported

It is evident that colistin alone significantly impacts the TCA cycle, with an overall trend of upregulated metabolic flux.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Transcriptome-constrained genome-scale metabolic modeling reveals central carbon and amino acid metabolic reprogramming underlying colistin-sulbactam synergy in &lt;i&gt;Acinetobacter baumannii&lt;/i&gt;.

The sentences

Transcriptome-constrained genome-scale metabolic modeling reveals central carbon and amino acid metabolic reprogramming underlying colistin-sulbactam synergy in <i>Acinetobacter baumannii</i>.