SUR1-TRPM4 is expressed in human epilepsy and promotes neuron hyperactivity and seizures in rodents.

Brain · 2026 · PMC13232044 · PMID 41239869

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a trend towards significanceno p-value reported

2 and Supplementary Figs 3 and 4 ) revealed significantly upregulated SUR1 in the temporal cortex (1.31 ± 0.04 fold-change), and a trend towards significance in the hippocampus (1.73 ± 0.57 fold-change) of PTZ-kindled mice compared with SHAM ( Fig. 2E and F ).

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