An LSEC-focused computational drug repurposing platform for liver fibrosis: Identification of vorinostat and other LSEC-protective candidates

bioRxiv · 2026 · PMC13232290

Europe PMC

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an increasing trendno p-value reported

On the other hand, ICAM1 showed an increasing trend without reaching significance.

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a decreasing trendno p-value reported

SAHA significantly reduced inflammation-related genes including ADGRE1 , TNF and IL18 , while CCL2 showed a decreasing trend ( Figure 4D , left ).

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