AURKA inhibitor VIC-1911 induces mitotic defects and functional BRCAness, sensitizing prostate cancer to PARP inhibition.

JCI Insight · 2026 · PMC13232484 · PMID 41915443

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Gene Ontology (GO) analyses of VIC-1911–induced genes revealed highly significant induction of the p53 pathway, which is known to become upregulated in response to DNA damage to trigger cell cycle arrest, initiate DNA repair, and/or induce cell death ( 25 ) ( Figure 2F ).

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