Aldosterone synthase inhibitors in uncontrolled and resistant hypertension: A phenotype-stratified systematic review and network meta-analysis of randomized trials.

PLoS One · 2026 · PMC13232938 · PMID 42234700

Europe PMC DOI

hedged sentence

0.0587

closest p · 1.2× alpha

0.0587

boldest claim

The sentences

marginally non-significantp = 0.0587so close (0.05 < p ≤ 0.1)

Hypotension was significantly increased (RR 2.67; 95% CI 1.45–4.92; p = 0.0112; I2 = 0%), with leave-one-out sensitivity analyses yielding stable estimates ranging from RR 2.33 to 2.86, though omitting Laffin 2025 rendered the result marginally non-significant (RR 2.66; 95% CI 0.93–7.56; p = 0.0587).

also in 1,493 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.