Universal transcriptomic hallmarks of mammalian ageing and mortality.

Clocks trained on genes involved in respiration/mitochondrial translation, oxidative phosphorylation/TCA cycle and cholesterol metabolism/mTOR signalling showed significantly increased tAge in both tissues, whereas NRF2 signalling/proteasome module clocks showed significant and marginally significant tAge acceleration in kidney and muscle, respectively.

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In old heterochronic parabionts, the rodent multi-tissue mortality clock detected a significant tAge reduction at the attached time point, whereas the chronological clock showed a nonsignificant trend (Fig. 6a and Extended Data Fig. 9a ).

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