Identification of novel reproducible combinatorial genetic risk factors for myalgic encephalomyelitis in the DecodeME patient cohort and commonalities with long COVID.

J Transl Med · 2026 · PMC13235158 · PMID 42015188

Europe PMC DOI

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highly significantp = 4 × 10 − 21actually significant

We observed a highly significant correlation between the signature count score and ME in the Test dataset (OR = 1.23 per standard deviation increase, p = 4 × 10 − 21 ) when including sex and the top 10 genetic principal components as confounders in the logistic regression.

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