Genomic heterogeneity of NAD(P)H dehydrogenase predisposes Cryptosporidium to clofazimine resistance.

Nat Microbiol · 2026 · PMC13236581 · PMID 42129495

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highly significantno p-value reported

A single narrowly defined quantitative trait locus (QTL) on chromosome 7 emerged; the statistical support for this locus increased with each round of treatment and dose escalation, with the most highly significant SNP exceeding a final G -value of 300 (Fig. 2c,d ).

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