Establishment of DNA methylation during primate germ cell development.

CH methylation occurred most frequently at CA dinucleotides, particularly at CAC and CAG trinucleotides, which showed an increasing trend across G1–G7 (Fig. 4F , left).

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These trinucleotides were enriched among methylated CpG sites but showed a decreasing trend from G1 to G7 (Fig. 4F , right), likely reflecting preferential methylation at early stages and reduced availability later.

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