Caloric restriction reprograms skeletal muscle molecular pathways in non-human primates: potential relevance to human aging biology.

Skelet Muscle · 2026 · PMC13237944 · PMID 42104473

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0100

boldest claim

The sentences

highly significantp < 0.01actually significant

In total, 29 genes were associated with at least one highly significant splicing variant ( p < 0.01).

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an overall trendno p-value reported

Notably, the CR group showed a greater number of underexpressed than overexpressed genes, reflecting an overall trend toward reduced transcript levels in skeletal muscle.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.