Reply to "Preclinical and Clinical Evidence on Chloroquine or Hydroxychloroquine in COVID-19": Achieving Statistical Significance Does Not Mean That Clinical Relevance Can Be Disregarded, and This Must Be Considered When Interpreting Results.

Clin Transl Sci · 2026 · PMC13239081 · PMID 42227593

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borderline significanceno p-value reported

While COPCOV suggests a modest signal in prophylaxis (RR ~0.85, borderline significance) [ 5 ], this effect is small, non‐clinically relevant (1% vs. 1.2%), and inconsistently observed across trials.

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