Evaluating the causal effect of mitochondrial dysfunction on Alzheimer's disease and Parkinson's disease using polygenic risk scores and Mendelian randomization.

Alzheimers Dement · 2026 · PMC13239222 · PMID 42163007

Europe PMC DOI

hedged sentence

0.0590

closest p · 1.2× alpha

0.0590

boldest claim

The sentences

a trend toward significancep = 0.059so close (0.05 < p ≤ 0.1)

However, the Longchamps mtDNAcn PRS showed a trend toward significance (odds ratio [OR; 95% confidence interval (CI)] = 0.97, [0.95–1.00], p = 0.059). 3.3 Univariable and MVMR showed no causal effect of mtDNAcn on AD or PD Univariate MR results show no significant causal effect of mtDNAcn onto AD, AD/dementia, or PD across all four mtDNAcn measures (Figure S2 in supporting information).

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