DAMP Laden Extracellular Vesicles From the Airways of Patients With Severe SARS-CoV-2 Respiratory Infection Compromise Inflammation and Cellular Metabolism.

While plasma‐derived sEVs from COVID‐19 patients had promoted a pro‐inflammatory response (Figure 4A ) the converse was seen with BAF‐derived sEVs with an overall trend for decreased cytokine production in monocytes exposed to BAF‐sEVs from COVID‐19 patients although this was only significant for IL‐6 and IFNα2 (Figure 5A ).

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