highly significantp = 1.75 × 10 −8
The mean granule diameter under MES was 0.018 μm (±0.014 μm), compared with 0.073 μm (±0.043 μm) in the control, corresponding to a 4.0‐fold difference that was highly significant (Welch's t ‐test, p = 1.75 × 10 −8 ).